“In some sense the problem is solved,” computational biologist John Moult declared in late 2020. The London-based company DeepMind had just swept a biennial contest co-founded by Moult that tests teams’ abilities to predict protein structures — one of biology’s grandest challenges — with its revolutionary artificial-intelligence (AI) tool AlphaFold.

Algorithms have helped mathematicians perform fundamental operations for thousands of years. The ancient Egyptians created an algorithm to multiply two numbers without requiring a multiplication table, and Greek mathematician Euclid described an algorithm to compute the greatest common divisor, which is still in use today.